- Checkpoint Mutants
- mad2∆
- bub2∆
- mad2∆ bub2∆
- cdc20-ts mad2∆
- cdc20-ts bub2∆
- WT in nocodazole
- mad2∆ in nocodazole
- mad2∆ GAL-TEM1 in nocodazole
- mad2∆ pds1∆ in nocodazole
- bub2∆ in nocodazole
- bub2∆ pds1∆ in nocodazole
- bub2∆ mad2∆ in nocodazole
- pds1∆ in nocodazole
- net1-ts in nocodazole
bub2∆ pds1∆ in nocodazole
debug: ,
test user =
test db =
Simulation:
Change of parameters: kbub2=0, ks1pds"=ks2pds"=0, ksspn=0, init BUB2=0.
Arrest: Mitotic exit at t=147.9 min.
Experiments:
Alexandru, G., Zachariae, W., Schleiffer, A. and Nasmyth, K. (1999). Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage. EMBO J. 18:2707-2721.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Fig. 6B, these mutants are not blocked in nococazole, they are able to exit from mitosis.
Comments: